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It inhibits histone demethylase JMJD3
American Journal of Cardiology
EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ
InChi: InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10
and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines
TAK1/MAP4K2 inhibitor 1 roacetate salt It inhibits histone demethylase JMJD3TAK1 MAP4K2 inhibitor 1 is a potent dual TGF activated kinase 1 (TAK1) and mitogen activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, with IC50s of 41. 1 nM and 18. 2 nM, respectively. Product information CAS Number: 1315330 11 0 Molecular Weight: 552. 59 Formula: C29H31F3N6O2 Synonym: Benzamide, N [4 [(4 ethyl 1 piperazinyl)methyl] 3 (trifluoromethyl)phenyl] 4 methyl 3 [(6 methyl 7H pyrrolo[2,3 d]pyrimidin 4 yl)oxy] Chemical Name: N
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